What You Need To Know About Cannabiniods (CBD, CBN, THC)
To begin we must take a dive into some of the basic science of cannabiniods, and have a look at CBD specifically as we scroll down a bit more.
I have done my best to provide scientific information. Nobody likes misinformation, my resources are well credited and reliable sources. there will be no speculation on my end, or in this blog at all. I believe firmly in allowing the reader to form an independent perspective and opinion. Let's get into this.
What are cannabiniods?
Cannabiniods are groups of compounds found in the medical plant: cannabis, think of them as the active ingredients of medical plant.
These compounds are found naturally in two places;
- The human body (endocannabiniod system)
- The medical plant itself, which led to the discovery of the endocannabiniod system.
Endocannabiniod system: short for endogenous cannabiniod system
Is believed to be the most important physiologic system involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. In each tissue, the cannabinoid system performs different tasks, but the goal is always the same: homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment.
One thing should remain clear: A functional cannabinoid system is essential for health. From embryonic implantation on the wall of our mother's uterus, to nursing and growth, to responding to injuries, endocannabinoids help us survive in a quickly changing and increasingly hostile environment.
The endocannabiniod system performs it's functions by utilizing a network of cannabiniod receptors found among a wide spectrum of human biology, our 5 human body systems and organs all contain receptors, though they are most potent in several areas of the brain.
More about cannabiniod receptors
The endocannabiniod system contains receptors which are responsible for picking up these compounds and responding to them thus producing the effects associated with the medical plant when it is used.
Consisting of 2 types of receptors CB1 and CB2.
- CB1 receptors are primarily found in the brain and central nervous system, and to a lesser extent in other tissues.
- CB2 receptors are mostly found in the perepheral organs especially cells associated with the immune system.
"Receptors are most dense in the basal ganglia, hippocampus, and cerebellum, and are sparse in the lower brainstem areas controlling heart and lung functions."
How Does CBD Affect the Endocannabinoid System?
The endocannabinoid system exists to respond to endogenous cannabinoids produced by the human body. However, scientists have learned that the system will also recognize and respond to cannabinoids from external sources, including the phytocannabinoid cannabidiol. According to the National Institutes of Health, manipulating the endocannabinoid system by introducing external cannabinoids like CBD could be useful in treating a variety of medical ailments.
CBD and Cannabinoid Receptors
The endocannabinoid system includes two primary types of receptors that bind to cannabinoids: CB1 and CB2. Unlike THC, which fits directly into the CB1 receptor, cannabidiol does not fit into either type of receptor perfectly. Instead, it stimulates activity in both receptors without actually binding to them. This results in changes within any cells that contain either receptor. Because CB1 and CB2 receptors are present throughout the body, the effects of CBD are systemic.
According to Project CBD, research has also shown that CBD counteracts the psychoactive effects of THC by inhibiting its effects on CB1 receptors.
CBD’s Indirect Effects on the Endocannabinoid System
When introduced into the endocannabinoid system, CBD causes an increased release of 2-AG, one of the endogenous cannabinoids. Like CBD, 2-AG stimulates both CB1 and CB2 receptors, which enhances the overall effect on the body. Studies published by the National Institutes of Health have shown that cannabidiol also inhibits the activity of fatty acid amide hydroxylase, or FAAH. This slows the deterioration of anandamide, another important endogenous cannabinoid found naturally within the body.
2-AG is present at relatively high levels in the central nervous system, with cannabinoid neuromodulatory effects, more about this HERE
Other Effects of CBD
In addition to its impact on the endocannabinoid system, CBD also affects the body in other ways. For example, CBD binds directly to a G-protein coupled receptor known as TRPV-1,
which is responsible for controlling body temperature, perceptions of pain and inflammation. CBD also activates serotonin receptors. Furthermore, studies conducted by the California Pacific Medical Center have shown that cannabidiol has the power to inhibit the ID-1 gene, which is known to cause several aggressive cancers, including certain cancers of the breast, brain, lungs, ovaries and pancreas. More on this HERE